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Inflammatory bowel disease The relationship between GLP-1 receptor agonists and inflammatory bowel disease is complicated by the gastrointestinal side effects these medications commonly cause

GLP-1 medications are not appropriate for people with a personal or family history of medullary thyroid carcinoma or MEN2 (Multiple Endocrine Neoplasia syndrome type 2), a history of pancreatitis, or anyone currently pregnant or breastfeeding

All three peptides distribute systemically after subcutaneous injection, but local tissue concentrations are highest within a 5 to 10 cm radius of the injection site